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MS Exchange 2010

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In my Organisation we are havingMS Exchange 2010 at DC & DR

When user is sending mail to any mail id internally or externally from POP3 configuration they are getting the below error

Your message did not reach some or all of the intended recipients.

Subject: Daily Report Server

Sent: 19/01/2013 11:12

The following recipient(s) cannot be reached:

nagash@denabank.co.in on 19/01/2013 11:12

550 5.7.1 Client does not have permissions to send as this sender

We given the solution for the above error 

In AD console we checked the "Send as" option in the Security tab

(Right click the particular mail id--> Click Properties-->Security-->Self-->Send as )

Then its working but that is not stable(Again the Send as option is disabled automatically) and User is facing the same problem again within five to ten minutes continuously

How to prevent this 

Thanks


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