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"0x8004010F: Outlook data file cannot be accessed." with multiple Exchange accounts

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A number of my users have multiple Exchange accounts loaded in their Outlook (2010), both located on my Exchange 2010 server.  The accounts are set up as separate users with different email addresses.  All my users have their primary email address (user@primary.com) as their default account, but some have this second email address (user@secondary.com) in their Outlook that's set up as a second Exchange account in their mail profile.  All the users can use the drop-down box in the From field to change what address they are sending with.

The problem seems to be relatively random, though, where they will send an email using their secondary address and it will get stuck in their Outbox and the Send/Receive dialog box displays the error "0x8004010F: Outlook data file cannot be accessed" with their secondary account showing the error.  Mail still flows to their secondary account and both to and from their primary.

Often times simply restarting Outlook allows the message to send, and it will appear in their Sent folder.  It's happening often enough, though, that my users are complaining and since there are a fair number of them, I'm getting at least one complaint a day, and telling them to restart Outlook isn't a viable long-term solution.  So far, I have tried, without success:

1) Creating a new Outlook profile.

2) Creating a new OST for both primary and secondary accounts.

3) Setting the secondary account to not use cached mode.  My thinking was no Outlook data file, no error about it not being accessed.  No such luck.

I'm just about at my wit's end.  Previously these accounts were hosted on a 3rd party server and accessed using POP/SMTP, so bringing the accounts in-house seemed like a no-brainer, but I just cannot get them to work properly.

Does anyone have any thoughts about either what else I could try, or even a best practices of how something like this *should* be set up, other than two Exchange accounts?  Thanks.


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